burden and typing of rotavirus group a in children with acute gastroenteritis in shiraz, southern iran
نویسندگان
چکیده
background human rotavirus is a significant cause of severe gastroenteritis in infants and young children worldwide. in recent years, rotavirus genotyping by rt-pcr has provided valuable information about the diversity of rotaviruses circulating worldwide. the purpose of the present study is to monitor the prevalence of the different g types of rotaviruses circulating in shiraz, southern iran and detect any uncommon or novel types. methods during the period from december 2007 to november 2008, a total of 138 stool samples were collected from children less than 5 years old who were hospitalized for acute gastroenteritis. rotavirus-associated diarrhea was investigated in fecal specimens with enzyme immunoassays (eia). rotavirus-positive specimens were typed by the nested rt-pcr and by using different types of specific primers. results out of the 138 collected samples, 34.78% (48 cases) tested positive for rotavirus. the frequency of g1, g2 and g4 types was 6.25%, 2.08% and 27.08%, respectively. mixed and non-typeable infections were detected in 33.34% and 31.25% of hospitalized children with acute diarrhea, respectively. this is the first time mixed rotavirus infections with g1/g3 have been reported in iran. conclusion the high frequency of rotavirus detection indicates the severity and the burden of rotavirus disease may be able to reduce through the implementation of an effective vaccine and continual surveillance for the detection of rotavirus genotypes circulating in other regions of iran. regarding to the noticeable frequency of non-typeable and mixed infections, it is suggested to use the other specific primers and further studies to detection of other novel and unusual types.
منابع مشابه
Burden and Typing of Rotavirus Group A in Children with Acute Gastroenteritis in Shiraz, Southern Iran
BACKGROUND Human Rotavirus is a significant cause of severe gastroenteritis in infants and young children worldwide. In recent years, Rotavirus genotyping by RT-PCR has provided valuable information about the diversity of Rotaviruses circulating worldwide. The purpose of the present study is to monitor the prevalence of the different G types of Rotaviruses circulating in Shiraz, Southern Iran a...
متن کاملFrequency of Rotavirus Infection in Children with Acute Gastroenteritis in Jahrom, South of Iran
Background: Rotavirus is a major cause of acute diarrhea in children worldwide. It is an important cause of death among young children in developing countries. The aim of this study was to evaluate the prevalence of rotavirus infection in children less than five years old hospitalized for gastroenteritis in Jahrom. Methods: One hundred and two stool samples were collected from children less tha...
متن کاملcorrigendum to: burden and typing of rotavirus group a in children with acute gastroenteritis in shiraz, southern iran [published in iran red cres med j. 2012;14(9): 531-540]
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عنوان ژورنال:
iranian red crescent medical journalجلد ۱۴، شماره ۹، صفحات ۵۳۱-۵۴۰
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